反应详情

10 mmole of 1-amino-3-nitroadamantane obtained by the method of Example 66 was dissolved in toluene (100 ml). To the resultant solution, 12 mmole of phosgene was added at the room temperature and stirred for 6 hours. As a result, The conversion of 1-amino-3-nitroadamantane was 99%, and 1-isocyanato-3-nitroadamantane (yield 90%) was formed.