反应详情

To 25.0 g of 6-bromo-2-naphthol and 22.0 g of 3,4-difluorophenylboric acid were added 100 ml of toluene, 50 ml of ethanol, 50 ml of a 2 N aqueous solution of potassium carbonate and 1.3 g of tetrakis(triphenylphosphine)palladium (0). The reaction mixture was heated under reflux for 3 hours. The reaction solution was then allowed to cool to room temperature. The resulting organic phase was separated, washed with water and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was then distilled off. The residue was purified through silica gel column chromatography (dichloromethane) to obtain 25.3 g of 6-(3,4-difluorophenyl)-2-naphthol.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 3 hours
3. customThe resulting organic phase was separated
4. washwashed with water and saturated brine
5. dry with materialdried over anhydrous sodium sulfate
6. distillationThe solvent was then distilled off
7. customThe residue was purified through silica gel column chromatography (dichloromethane)