Sodium Thiosulfate → HCID 9887398, compound

Participants

Reaction Steps

To a solution of 6-acetyl-2-(3-chlorophenyl)-5-methyl-4-phenylthio-3(2H)-pyridazinone (0.37 g) in 1,2-dichloroethane (10 ml) was added m-chloroperbenzoic acid (0.65 g), followed by stirring at room temperature for 12 hours. An aqueous solution of sodium thiosulfate was added to the reaction mixture to decompose excess oxidizing agent, and then the mixture was extracted with chloroform. After washing with a saturated aqueous sodium hydrogen carbonate solution and a brine, the organic layer was dried over anhydrous magnesium sulfate. The solvent was removed by evaporation, and the resulting residue was allowed to stand at room temperature to obtain crystalline 6-acetyl-2-(3-chlorophenyl)-5-methyl-4-phenylsulfonyl-3(2H)-pyridazinone (0.38 g) (Compound No. 1-83).

Provenance & Evidence