Sodium Thiosulfate → HCID 9887398, compound

HRID 992262Notes

Reaction equation

HRID 992262 reaction equation
[C:1]([C:4]1[C:5]([CH3:25])=[C:6](SC2C=CC=CC=2)[C:7](=[O:17])[N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[N:9]=1)(=[O:3])[CH3:2].Cl[C:27]1[CH:32]=[CH:31][CH:30]=[C:29](C(OO)=O)[CH:28]=1.[S:37]([O-:41])([O-])(=[O:39])=S.[Na+].[Na+]>ClCCCl>[C:1]([C:4]1[C:5]([CH3:25])=[C:6]([S:37]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)(=[O:41])=[O:39])[C:7](=[O:17])[N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[N:9]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 24477Sodium ThiosulfateHCID 70297m-Chloroperbenzoic acidHCID 9820727HCID 9820727, compound

Product 1

HCID 9887398HCID 9887398, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

To a solution of 6-acetyl-2-(3-chlorophenyl)-5-methyl-4-phenylthio-3(2H)-pyridazinone (0.37 g) in 1,2-dichloroethane (10 ml) was added m-chloroperbenzoic acid (0.65 g), followed by stirring at room temperature for 12 hours. An aqueous solution of sodium thiosulfate was added to the reaction mixture to decompose excess oxidizing agent, and then the mixture was extracted with chloroform. After washing with a saturated aqueous sodium hydrogen carbonate solution and a brine, the organic layer was dried over anhydrous magnesium sulfate. The solvent was removed by evaporation, and the resulting residue was allowed to stand at room temperature to obtain crystalline 6-acetyl-2-(3-chlorophenyl)-5-methyl-4-phenylsulfonyl-3(2H)-pyridazinone (0.38 g) (Compound No. 1-83).

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washAfter washing with a saturated aqueous sodium hydrogen carbonate solution
  3. dry with materiala brine, the organic layer was dried over anhydrous magnesium sulfate
  4. customThe solvent was removed by evaporation
  5. customto stand at room temperature

Sources & evidence

ORD record
ord-8a5b4f9e24ec4753a84470b805f3ba45
Source dataset
uspto-grants-2002_10
Patent number
US06469003B1

Reaction notes

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