反应详情

温度

160 °C

1-Benzyl-3-(p-toluenesulfonyloxy)pyrrolidine (3.3 g) and aniline (1.3 g) were mixed and stirred under heating at 160° C. for 3 hours. After the completion of the reaction, the mixture was cooled to room temperature, and an aqueous potassium carbonate solution was added thereto. The obtained mixture was extracted with chloroform, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was subjected to silica gel column chromatography (chloroform:methanol=40:1). The obtained eluate was concentrated to give 3-anilino-1-benzylpyrrolidine (1.2 g).

1. customAfter the completion of the reaction
2. temperaturethe mixture was cooled to room temperature
3. extractionThe obtained mixture was extracted with chloroform
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated under reduced pressure
6. concentrationThe obtained eluate was concentrated