反应详情

3-Anilinopyrrolidine (0.67 g) and 2-(4-fluorophenyl)ethyl p-toluenesulfonate (1.2 g) were dissolved in acetonitrile (20 ml), and potassium carbonate (2 g) was added. The mixture was refluxed for 3 hours, and after the completion of the reaction, the solvent was evaporated under reduced pressure. The obtained residue was dissolved in ethyl acetate, washed with an aqueous potassium carbonate solution, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was subjected to silica gel column chromatography (chloroform:methanol=20:1). The obtained eluate was concentrated to give 3-anilino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine (0.83 g).

1. temperatureThe mixture was refluxed for 3 hours
2. customafter the completion of the reaction
3. customthe solvent was evaporated under reduced pressure
4. dissolutionThe obtained residue was dissolved in ethyl acetate
5. washwashed with an aqueous potassium carbonate solution
6. dry with materialdried over magnesium sulfate
7. customThe solvent was evaporated under reduced pressure
8. concentrationThe obtained eluate was concentrated