Dicyclohexylacetic acid → (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)dicyclohexylacetamide

HRID 992297노트

반응식

HRID 992297 반응식
[CH:1]1([CH:7]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[C:8]([OH:10])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C@H:18]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH2:19]1>>[F:31][C:28]1[CH:29]=[CH:30][C:25]([CH2:24][CH2:23][N:20]2[CH2:21][CH2:22][C@H:18]([NH:17][C:8](=[O:10])[CH:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]3)[CH2:19]2)=[CH:26][CH:27]=1

참가 물질

3

반응물 2

HCID 3661562Dicyclohexylacetic acidHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

생성물 1

HCID 59915903(S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)dicyclohexylacetamide수율 26.5%

실험 절차

Dicyclohexylacetic acid (0.45 g) and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine (0.42 g) were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)dicyclohexylacetamide (0.22 g), melting point 122-124° C.

출처 및 근거

ORD 기록
ord-12b5a980701045a28b9a9d228ac359c4
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06468998B1

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