反应详情

(S)-3-Amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine (0.42 g) and triethylamine (0.28 ml) were dissolved in methylene chloride (10 ml), and carbazole-N-carbonyl chloride (0.46 g) was added under ice-cooling. After the completion of the reaction, water was added, and the mixture was extracted with chloroform and dried over magnesium sulfate. The solvent was evaporated under reduced pressure, and IPE was added to the obtained residue. The precipitated crystals were collected by filtration to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)carbazole-9-carboxamide (0.38 g), melting point 107-108° C.

1. temperaturecooling
2. additionwas added
3. extractionthe mixture was extracted with chloroform
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated under reduced pressure, and IPE
6. additionwas added to the obtained residue
7. filtrationThe precipitated crystals were collected by filtration