(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine → (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-azabicyclo[2.2.2]octane-4-carboxamide

HRID 992340Notes

Reaction equation

HRID 992340 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9](Cl)=[O:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[NH2:12][C@H:13]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:14]1>>[C:20]1([CH2:19][CH2:18][N:15]2[CH2:16][CH2:17][C@H:13]([NH:12][C:9]([C:4]34[CH2:7][CH2:8][N:1]([CH2:6][CH2:5]3)[CH2:2][CH2:3]4)=[O:10])[CH2:14]2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 10774056(3S)-1-(2-Phenylethyl)-3-pyrrolidinamineHCID 137609401-Azabicyclo[2.2.2]octane-4-carbonyl chloride

Product 1

HCID 22888074(S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-azabicyclo[2.2.2]octane-4-carboxamide

Procedure

1-Azabicyclo[2.2.2]octane-4-carbonyl chloride and (S)-3-amino-1-(2-phenylethyl)pyrrolidine were reacted under the same conditions as in Example 53 to give (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-azabicyclo[2.2.2]octane-4-carboxamide.

Sources & evidence

ORD record
ord-b9005c185528441c8289d14214815d8e
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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