Potassium Carbonate → HCID 506296, compound

HRID 992359Notes

Reaction equation

HRID 992359 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:28])[C:16]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][C:25]=3[F:27])[NH:20][CH:19]=2)=[O:17])[CH:11]([C:29]([O:31]CC)=[O:30])[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO.O>[C:1]([N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:28])[C:16]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][C:25]=3[F:27])[NH:20][CH:19]=2)=[O:17])[CH:11]([C:29]([OH:31])=[O:30])[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 18412089HCID 18412089, compound

Product 1

HCID 506296HCID 506296, compoundYield 23.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a stirred solution of N-(benzoyl)-3-ethoxycarbonyl-N′-[(4-fluoro-indol-3-yl)-oxoacetyl]-piperazine (100 mg, 0.02 mmol) in methanol (1 ml) and water (1 ml), was added potassium carbonate (9 mg, 0.06 mmol). After stirring for 8 hours at room temperature, the product was concentrated in vacuo to give a residue which was purified by preparative HPLC to yield 2 mg of N-(benzoyl)-3-hydroxycarbonyl-N′-[(4-fluoro-indol-3-yl)-oxoacetyl]-piperazine (Example 101).

Workup

  1. concentrationthe product was concentrated in vacuo
  2. customto give a residue which
  3. customwas purified by preparative HPLC

Sources & evidence

ORD record
ord-1b081bac800847d5897c1b387bb6a936
Source dataset
uspto-grants-2002_10
Patent number
US06469006B1

Reaction notes

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