反应详情

To a 100 ml methanol solution of 3.51 g of the compound (8) synthesized in Example 1 were added 200 mg of palladium carbon and 1 ml of acetic acid for hydrogenation at atmospheric pressure and room temperature. After the completion of the reaction, the insolubles were filtered off, then the filtrate was concentrated under reduced pressure. The obtained residue was dissolved in methylene chloride and adjusted by a 10% aqueous solution of sodium hydroxide to a pH 9 to 10, then was shaken. The organic layer was dried, filtered, then condensed under reduced pressure to obtain a residue which was then purified by silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the above-referenced compound (9) in an amount of 2.32 g (yield 66%).

1. customAfter the completion of the reaction
2. filtrationthe insolubles were filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. dissolutionThe obtained residue was dissolved in methylene chloride
5. customThe organic layer was dried
6. filtrationfiltered
7. customcondensed under reduced pressure
8. customto obtain a residue which
9. customwas then purified by silica gel column chromatography (methylene chloride:methanol=20:1)