反应详情

To an 8 ml acetonitrile solution of 300 mg of the compound (8) synthesized in Example 1 were added 234 mg cinnamyl bromide and 0.5 ml of triethylamine. This was then heated and refluxed for 3 hours. To the reaction mixture was added 10 ml of ice water. This was then extracted with ethyl acetate. The extract was dried, filtered, then concentrated under reduced pressure to obtain a residue which was then purified by silica gel column chromatography (methylene chloride:methanol=25:1) to obtain the above-referenced compound (18) in an amount of 320 mg (yield 73%).

1. temperatureThis was then heated
2. temperaturerefluxed for 3 hours
3. extractionThis was then extracted with ethyl acetate
4. customThe extract was dried
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. customto obtain a residue which
8. customwas then purified by silica gel column chromatography (methylene chloride:methanol=25:1)