反应详情

To an 8 ml tetrahydrofuran solution of 400 mg of the compound (5) synthesized in Reference Example 5 was added under ice cooling 60 mg of lithium aluminum hydride, then the resulting mixture was stirred at room temperature for two hours. A 10% aqueous solution of sodium hydroxide solution was added, then the product was extracted with methylene chloride. The extract was dried, filtered, then concentrated under reduced pressure to obtain a residue which was then purified by silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the above-referenced compound (19) in an amount of 273 mg (yield 72%).

1. extractionthe product was extracted with methylene chloride
2. customThe extract was dried
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customto obtain a residue which
6. customwas then purified by silica gel column chromatography (methylene chloride:methanol=20:1)