2-Bromopropiophenone → 1-(1-Benzoylethyl)-4-(4-phenoxyphenyl)piperidine
Reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH:21]([CH3:30])[C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:23]>>[C:22]([CH:21]([N:17]1[CH2:18][CH2:19][CH:14]([C:11]2[CH:12]=[CH:13][C:8]([O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:9][CH:10]=2)[CH2:15][CH2:16]1)[CH3:30])(=[O:23])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1Participants
3
Procedure
The same procedure was followed as in Example 11 using the compound (9) synthesized in Example 2 and 2-bromopropiophenone to produce the above.
Workup
- customto produce the above
Sources & evidence
- ORD record
- ord-6d3cb8ae7aaa4585a87f97b2b98d81ce
- Source dataset
- uspto-grants-2002_10
- Patent number
- US06469010B1
Reaction notes
Loading…