HCID 178427889, compound → HCID 178427891, compound

HRID 992389Notes

Reaction equation

HRID 992389 reaction equation
O1CCCCC1[O:7][NH:8][C:9]([C:11]1[C:19]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[CH3:28])=[C:18]([F:29])[C:14]2[NH:15][CH:16]=[N:17][C:13]=2[CH:12]=1)=[O:10]>Cl.CO.C(O)C>[OH:7][NH:8][C:9]([C:11]1[C:19]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[CH3:28])=[C:18]([F:29])[C:14]2[NH:15][CH:16]=[N:17][C:13]=2[CH:12]=1)=[O:10]

Participants

5

Reactant 1

HCID 178427889HCID 178427889, compound

Product 1

HCID 178427891HCID 178427891, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

The compound 7-fluoro-6-(4-iodo-2-methyl-phenylamino)-1H-benzoimidazole-5-carboxylic acid O-(tetrahydro-2H-pyran-2-yl)-oxyamide is dissolved in an appropriate hydrogen chloride-saturated solvent like methanol or ethanol. Once homogeneous, the solution is concentrated in vacuo to give the desired product. The product may be triturated with an appropriate solvent like chloroform or dichloromethane if further purification is necessary.

Workup

  1. concentrationOnce homogeneous, the solution is concentrated in vacuo

Sources & evidence

ORD record
ord-84d4418183804a0bb7205d548ecdf554
Source dataset
uspto-grants-2002_10
Patent number
US06469004B1

Reaction notes

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