Sodium Azide → HCID 69628011, compound

HRID 992399Notes

Reaction equation

HRID 992399 reaction equation
[F:1][C:2]1[C:10]2[C:6](=[N:7][O+:8]([O-])[N:9]=2)[CH:5]=[C:4]([C:12]([O:14][CH3:15])=[O:13])[C:3]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23].[N-]=[N+]=[N-].[Na+]>C(O)CO>[F:1][C:2]1[C:10]2[C:6](=[N:7][O:8][N:9]=2)[CH:5]=[C:4]([C:12]([O:14][CH3:15])=[O:13])[C:3]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 86759978HCID 86759978, compound

Product 1

HCID 69628011HCID 69628011, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Conditions

Temperature
145 °C

Procedure

A solution comprised of methyl 7-fluoro-6-(2-methyl-phenylamino)-benzo[1,2,5]oxadiazole-5-carboxylate 2-oxide and sodium azide (1.38 equiv.) in ethylene glycol is heated to 140-150° C. for 30 minutes to obtain, after column chromatography, the desired product.

Workup

  1. customto obtain

Sources & evidence

ORD record
ord-5fd0ee10bafd49809bbe3c24295264de
Source dataset
uspto-grants-2002_10
Patent number
US06469004B1

Reaction notes

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