反应详情

11.4 g (63 mMol) of 4-cyano-phenoxyacetic acid were dissolved in 200 ml of absolute tetrahydrofuran and mixed at room temperature with 10.2 g (63 mMol) of N,N′-carbonyldiimidazole. After 15 minutes at 60° C., 5.70 g (41.5 mMol) of 2-amino-3-methylamino-6-methyl-pyridine were added. After 2 hours at 60° C. the solvent was distilled off and the crystalline residue was mixed with water, washed with water and dried. After crystallisation from ethanol 9.95 g (91% of theory) were obtained in the form of white crystals.

1. distillationAfter 2 hours at 60° C. the solvent was distilled off
2. additionthe crystalline residue was mixed with water
3. washwashed with water
4. customdried
5. customAfter crystallisation from ethanol 9.95 g (91% of theory)
6. customwere obtained in the form of white crystals