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HRID992640

反应详情

EQUATION

反应方程式

HRID 992640 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1
HCID87949

p-Anisyldithiophosphonic anhydride

C14H14O2P2S4

结构：COCC(=O)Nc1cc(C(=O)OC)cnc1Cl
HCID18412377

未命名化合物

PRODUCTS

生成物

1
结构：COCc1nc2cc(C(=O)OC)cnc2s1
HCID18412416

Methyl 2-(methoxymethyl)thiazolo[5,4-b]pyridine-6-carboxylate

C10H10N2O3S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1C
溶剂HCID7237

o-Xylene

C8H10

PROCEDURE

实验过程

A mixture of 0.53 g (2.05 mMol) of methyl 6-chloro-5-methoxyacetamido-nicotinate and 0.42 g (1.0 mMol) of Lawessons reagent was refluxed for 16 hours in 25 ml of xylene. After the solvent had been removed in vacuo the crude product obtained was purified by flash chromatography (silica gel; methylene chloride/ethanol=100:1) and evaporated down again in vacuo.

WORKUP

后处理

  1. customAfter the solvent had been removed in vacuo the crude product
  2. customobtained
  3. customwas purified by flash chromatography (silica gel; methylene chloride/ethanol=100:1)
  4. customevaporated down again in vacuo