HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 992713Generated: October 30, 2026
Hydrochloric Acid → 7beta-[2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylic acid dihydrochloride
https://huagongshe.com/reaction/992713
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 9826491 | HCID 9826491 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7beta-[2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylic acid dihydrochloride | HCID 131723598 | — |
Reaction Steps
7β-[2-(2-Aminothiazol-4-yl)-2-(Z)-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylic acid (283 mg) was suspended in water (100 ml) and 1.25 ml of 1N hydrochloric acid was added thereto. The mixture was stirred at 40° C. for 10 minutes and then lyophilized to afford 7β-[2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylic acid dihydrochloride (281.8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06468995B1 |
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| Source dataset | uspto-grants-2002_10 |
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| ORD ID | ord-8703c2308b344544a3b726ea25411995 |
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| Source note | uspto-grants-2002_10 |
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