Hydrochloric Acid → 7beta-[2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylic acid dihydrochloride

HRID 992713Notes

Reaction equation

HRID 992713 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:30]/[OH:31])/[C:8]([NH:10][C@@H:11]2[C:28](=[O:29])[N:13]3[C:14]([C:25]([OH:27])=[O:26])=[C:15]([S:18][CH2:19][C:20]4[CH:21]=[N:22][NH:23][CH:24]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1.[ClH:32]>O>[ClH:32].[ClH:32].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:30][OH:31])[C:8]([NH:10][C@@H:11]2[C:28](=[O:29])[N:13]3[C:14]([C:25]([OH:27])=[O:26])=[C:15]([S:18][CH2:19][C:20]4[CH:21]=[N:22][NH:23][CH:24]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9826491HCID 9826491, compound

Product 1

HCID 1317235987beta-[2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylic acid dihydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

7β-[2-(2-Aminothiazol-4-yl)-2-(Z)-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylic acid (283 mg) was suspended in water (100 ml) and 1.25 ml of 1N hydrochloric acid was added thereto. The mixture was stirred at 40° C. for 10 minutes and then lyophilized to afford 7β-[2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylic acid dihydrochloride (281.8 mg).

Sources & evidence

ORD record
ord-8703c2308b344544a3b726ea25411995
Source dataset
uspto-grants-2002_10
Patent number
US06468995B1

Reaction notes

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