Tetrahydrofuran → 4-(4-bromo-2-tert-butyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine
Reaction equation
[Br:6][c:7]1[n:8][c:9]([C:21]([CH3:22])([CH3:23])[CH3:24])[n:10]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:18])([CH3:19])[CH3:20])[c:11]1[Br:12].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[Cl:25][c:26]1[n:27][cH:28][cH:29][cH:30][n:31]1.[O:37]=[Mn:38]=[O:39]>>[Br:6][c:7]1[n:8][c:9]([C:21]([CH3:22])([CH3:23])[CH3:24])[n:10]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:18])([CH3:19])[CH3:20])[c:11]1-[c:28]1[n:27][c:26]([Cl:25])[n:31][cH:30][cH:29]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-886c01a5d5ac40d2aed9e2bff3da1229
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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