Piperazine → HCID 10146456, compound

HRID 992996Notes

Reaction equation

HRID 992996 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[N:10]=[C:11]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=2)[S:12][CH:13]=1)(=O)=O.[NH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH3:25][O:24][C:16]1[CH:15]=[C:14]([C:11]2[S:12][CH:13]=[C:9]([CH2:8][CH2:7][CH2:6][N:26]3[CH2:31][CH2:30][N:29]([CH2:6][CH2:7][CH2:8][C:9]4[N:10]=[C:11]([C:14]5[CH:15]=[C:16]([O:24][CH3:25])[C:17]([O:22][CH3:23])=[C:18]([O:20][CH3:21])[CH:19]=5)[S:12][CH:13]=4)[CH2:28][CH2:27]3)[N:10]=2)[CH:19]=[C:18]([O:20][CH3:21])[C:17]=1[O:22][CH3:23]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 18408520HCID 18408520, compound

Product 1

HCID 10146456HCID 10146456, compound

Procedure

4-(3-Methanesulfonyloxypropyl)-2-(3,4,5-trimethoxy-phenyl)thiazole (310 mg) and piperazine (34 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-1b526252dcab4ab9af7b4a1b4537dfae
Source dataset
uspto-grants-2002_10
Patent number
US06472386B1

Reaction notes

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