反应详情

Ethyl 2-(3,4,5-trimethoxyphenylethynyl)thiazole-4-carboxylate (200 mg) was suspended in methanol (2 mL), to the suspension a 4 M solution (1 mL) of sodium hydroxide was added, and the mixture was stirred at room temperature for 4 hours. Concentrated hydrochloric acid was added dropwise to the reaction mixture at 0° C. to weakly acidify the reaction mixture. Crystals formed were collected by filtration, washed with water and dried to obtain the title compound.

1. additionwas added
2. customCrystals formed
3. filtrationwere collected by filtration
4. washwashed with water
5. customdried