Piperazine → HCID 9853095, compound

HRID 993004Notes

Reaction equation

HRID 993004 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([NH:8][C:9](=[O:22])[C:10]2[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=2)[S:6][CH:7]=1.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:21][O:20][C:12]1[CH:11]=[C:10]([CH:15]=[C:14]([O:16][CH3:17])[C:13]=1[O:18][CH3:19])[C:9]([NH:8][C:5]1[S:6][CH:7]=[C:3]([CH2:2][N:23]2[CH2:28][CH2:27][N:26]([CH2:2][C:3]3[N:4]=[C:5]([NH:8][C:9](=[O:22])[C:10]4[CH:11]=[C:12]([O:20][CH3:21])[C:13]([O:18][CH3:19])=[C:14]([O:16][CH3:17])[CH:15]=4)[S:6][CH:7]=3)[CH2:25][CH2:24]2)[N:4]=1)=[O:22]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 18408491HCID 18408491, compound

Product 1

HCID 9853095HCID 9853095, compound

Procedure

4-Chloromethyl-2-(3,4,5-trimethoxybenzamido)-thiazole (140 mg) and piperazine (17 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-770439ec11e24e9f8542012010b9571c
Source dataset
uspto-grants-2002_10
Patent number
US06472386B1

Reaction notes

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