Piperazine → HCID 10211550, compound

HRID 993006Notes

Reaction equation

HRID 993006 reaction equation
Cl[CH2:2][C:3]1[S:7][C:6]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)=[N:5][C:4]=1[CH3:20].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:20][C:4]1[N:5]=[C:6]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)[S:7][C:3]=1[CH2:2][N:21]1[CH2:26][CH2:25][N:24]([CH2:2][C:3]2[S:7][C:6]([C:8]3[CH:9]=[C:10]([O:18][CH3:19])[C:11]([O:16][CH3:17])=[C:12]([O:14][CH3:15])[CH:13]=3)=[N:5][C:4]=2[CH3:20])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 18408505HCID 18408505, compound

Product 1

HCID 10211550HCID 10211550, compound

Procedure

5-Chloromethyl-4-methyl-2-(3,4,5-trimethoxy-phenyl)thiazole (104 mg) and piperazine (13 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-00d6edf61ef44d0791a55a4bfead566d
Source dataset
uspto-grants-2002_10
Patent number
US06472386B1

Reaction notes

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