Piperazine → HCID 10281741, compound

HRID 993026Notes

Reaction equation

Cl[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)[O:5][N:4]=1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH3:19][O:18][C:10]1[CH:9]=[C:8]([C:6]2[O:5][N:4]=[C:3]([CH2:2][N:20]3[CH2:25][CH2:24][N:23]([CH2:2][C:3]4[CH:7]=[C:6]([C:8]5[CH:9]=[C:10]([O:18][CH3:19])[C:11]([O:16][CH3:17])=[C:12]([O:14][CH3:15])[CH:13]=5)[O:5][N:4]=4)[CH2:22][CH2:21]3)[CH:7]=2)[CH:13]=[C:12]([O:14][CH3:15])[C:11]=1[O:16][CH3:17]

Participants

Reactant 2

HCID 4837Piperazine

HCID 18408512HCID 18408512, compound

Product 1

HCID 10281741HCID 10281741, compound

Procedure

3-Chloromethyl-5-(3,4,5-trimethoxyphenyl)isoxazole (170 mg) and piperazine (26 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record: ord-972aea1213ff4854a3b3085a4bd40a64
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06472386B1

Reaction notes

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