Proton sponge → Ethyl 4-[[4-[1-(1-Acetoxypropyl)oxycarbonylpiperidin-4-yl]-2-oxopiperazin-1-yl]acetyl]phenoxyacetate Hydrochloride

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Reaction Steps

The title compound was prepared in a yield of 115 mg (100%) as a free base from 101 mg of ethyl 4-[[2-oxo-4-(piperidin-4-yl)piperazin-1-yl]acetyl]phenoxyacetate dihydrochloride synthesized according to the method described in WO962503 in the same manner as in Example 8 except that N,N-dimethylformamide, proton sponge and 1-acetoxypropyl 4-nitrophenyl carbonate were used in an amount of 2 ml, 101 mg and 82.8 mg, respectively.

Provenance & Evidence