HRID993042

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID88675

1,8-Bis(dimethylamino)naphthalene

C14H18N2

结构：CCOC(=O)COc1ccc(C(=O)CN2CCN(C3CCNCC3)CC2=O)cc1.Cl.Cl

HCID18408903

未命名化合物

结构：CCC(OC(C)=O)OC(=O)Oc1ccc([N+](=O)[O-])cc1

HCID18408941

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)COc1ccc(C(=O)CN2CCN(C3CCN(C(=O)OC(CC)OC(C)=O)CC3)CC2=O)cc1.Cl

HCID18408934

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The title compound was prepared in a yield of 115 mg (100%) as a free base from 101 mg of ethyl 4-[[2-oxo-4-(piperidin-4-yl)piperazin-1-yl]acetyl]phenoxyacetate dihydrochloride synthesized according to the method described in WO962503 in the same manner as in Example 8 except that N,N-dimethylformamide, proton sponge and 1-acetoxypropyl 4-nitrophenyl carbonate were used in an amount of 2 ml, 101 mg and 82.8 mg, respectively.

WORKUP

后处理

customsynthesized

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8ede12e261d24b9190bb23a0bf29dd1b
来源数据集: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06472397B1
来源说明: uspto-grants-2002_10

反应 SMILES

[ClH:1].Cl.[O:3]=[C:4]1[CH2:9][N:8]([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH2:7][CH2:6][N:5]1[CH2:16][C:17]([C:19]1[CH:31]=[CH:30][C:22]([O:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:21][CH:20]=1)=[O:18].CN(C1C2C(N(C)C)=CC=CC=2C=CC=1)C.[C:48](=O)([O:57]C1C=CC([N+]([O-])=O)=CC=1)[O:49][CH:50]([O:53][C:54](=[O:56])[CH3:55])[CH2:51][CH3:52]>CN(C)C=O>[ClH:1].[C:54]([O:53][CH:50]([O:49][C:48]([N:13]1[CH2:12][CH2:11][CH:10]([N:8]2[CH2:7][CH2:6][N:5]([CH2:16][C:17]([C:19]3[CH:31]=[CH:30][C:22]([O:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:21][CH:20]=3)=[O:18])[C:4](=[O:3])[CH2:9]2)[CH2:15][CH2:14]1)=[O:57])[CH2:51][CH3:52])(=[O:56])[CH3:55]