HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 993050Generated: October 26, 2026
Thionyl Chloride → 3-(4-Methoxyphenyl)propionyl chloride
https://huagongshe.com/reaction/993050
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(p-Methoxyphenyl)propionic acid | HCID 95750 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(4-Methoxyphenyl)propionyl chloride | HCID 10932441 | — |
Reaction Steps
To a suspension of 3-(4-Methoxyphenyl)propionic acid (10 g) in 150 ml of toluene are added 8 ml of thionyl chloride and the mixture is heated to 65° C. for 4 hours. The solvent is evaporated off under reduced pressure and the residue is redissolved in toluene and concentrated to dryness. Such steo is repeated twice. 11 g of the product are obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06472396B1 |
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| Source dataset | uspto-grants-2002_10 |
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| ORD ID | ord-40fd248ea35049fdbad7ae1df8c27c33 |
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| Source note | uspto-grants-2002_10 |
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