反应详情

To a suspension of barbituric Acid (6.4 g) in 48 ml of pyridine are added dropwise 11 g of 3-(4-Methoxyphenyl)propionyl chloride and the mixture is stirred at room temperature for 18 hours. The reaction mixture is then poured into ice and acidified to pH=1 by adding 6 N hydrochloric acid. A solid precipitates, which is filtered and resuspended in methanol. The suspension is kept under stirring for 15 minutes, then the solid is recovered by filtration to give 12.2 g of the product m.p. 248-250° C.

1. additionThe reaction mixture is then poured into ice
2. customA solid precipitates
3. filtrationwhich is filtered
4. stirringunder stirring for 15 minutes
5. filtrationthe solid is recovered by filtration