反应详情

A of 5-Bromo-5-[3-(4-Methoxyphenyl)propyl]barbituric Acid (710 mg) and N-(2-hydroxyethyl)piperazine (281 mg) in 25 ml of ethanol is refluxed for 4 hours. The solvent is evaporated under reduced pressure and the residue is partitioned between 1 N hydrochloric acid and ethyl acetate. The aqueous phase is basified to pH=6-7 and extracted with ethyl acetate. The organic phase is concentrated to dryness and the residue is crystallized from ethyl acetate to give 30 mg of the product.

1. customThe solvent is evaporated under reduced pressure
2. customthe residue is partitioned between 1 N hydrochloric acid and ethyl acetate
3. extractionextracted with ethyl acetate
4. concentrationThe organic phase is concentrated to dryness
5. customthe residue is crystallized from ethyl acetate