1-(2-Hydroxyethyl)piperazine → 5-[3-(4-Methoxyphenyl)propyl]-5-[4-(2-hydroxyethyl)piperazinyl]barbituric Acid

Participants

Reaction Steps

A of 5-Bromo-5-[3-(4-Methoxyphenyl)propyl]barbituric Acid (710 mg) and N-(2-hydroxyethyl)piperazine (281 mg) in 25 ml of ethanol is refluxed for 4 hours. The solvent is evaporated under reduced pressure and the residue is partitioned between 1 N hydrochloric acid and ethyl acetate. The aqueous phase is basified to pH=6-7 and extracted with ethyl acetate. The organic phase is concentrated to dryness and the residue is crystallized from ethyl acetate to give 30 mg of the product.

Provenance & Evidence