Hydrogen Bromide → HCID 1380839, compound

HRID 993060Notes

Reaction equation

HRID 993060 reaction equation
[CH2:1]([CH:8]1[C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10][C:9]1=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BrH:17].BrBr>O>[Br:17][C:8]1([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9](=[O:16])[NH:10][C:11](=[O:15])[NH:12][C:13]1=[O:14]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 260790MLS002695130

Product 1

HCID 1380839HCID 1380839, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
2.5 °C

Procedure

To a suspension of 5-benzylbarbituric Acid (1.7 g) in 15 ml of water, cooled to 0-5° C. 1 ml of 48% hydrobromic acid are added followed by the addition dropwise of 0.437 ml of bromine into the reaction mixture. After 1 hour under stirring at a temperature below 10° C. the solid which formed is separated by filtration and washed with water. 2.17 g of the product are obtained, m.p. 164-166° C.

Workup

  1. customformed
  2. customis separated by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-fad1315b5c494a9294200d83411c36f6
Source dataset
uspto-grants-2002_10
Patent number
US06472396B1

Reaction notes

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