反应详情

To a solution of 2-naphtylacetic acid (5 g) in 50 ml of ethanol are added 0.5 g of paratoluensulfonic acid, then the reaction mixture is refluxed for about 4 hours. The solvent is evaporated off and the residue is dissolved in diethyl ether, washed twice with a saturated aqueous solution of sodium hydrogencarbonate and once with brine, then the pooled organic extracts are dried over sodium sulfate and concentrated to dryness. 5.64 g of the product as a yellow oil are obtained.

1. temperaturethe reaction mixture is refluxed for about 4 hours
2. customThe solvent is evaporated off
3. dissolutionthe residue is dissolved in diethyl ether
4. washwashed twice with a saturated aqueous solution of sodium hydrogencarbonate and once with brine
5. dry with materialthe pooled organic extracts are dried over sodium sulfate
6. concentrationconcentrated to dryness