Hydrogen Bromide → HCID 18408799, compound

HRID 993084Notes

Reaction equation

HRID 993084 reaction equation
[CH2:1]([CH:11]1[C:16](=[O:17])[NH:15][C:14](=[O:18])[NH:13][C:12]1=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[BrH:20].BrBr>O>[Br:20][C:11]1([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[C:16](=[O:17])[NH:15][C:14](=[O:18])[NH:13][C:12]1=[O:19]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 18408739HCID 18408739, compound

Product 1

HCID 18408799HCID 18408799, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

To a suspension of 5-decylbarbituric Acid (0.537 g) in 2.9 ml of water are added under stirring at room temperature 0.29 ml of 48% hydrobromic acid. The mixture is cooled to 0° C. and 0.113 ml of bromine are dropped. The reaction mixture is stirred at room temperature for 1 hour 30 minutes, then the white precipitate is filtered and it is washed with water. The solid is partitioned between water and diethyl ether, the organic phase is separated, washed with brine and finally dried over sodium sulfate. By evaporation of the solvent under reduced pressure 0.62 g of the product are recovered.

Workup

  1. additionare added
  2. filtrationthe white precipitate is filtered
  3. washit is washed with water
  4. customThe solid is partitioned between water and diethyl ether
  5. customthe organic phase is separated
  6. washwashed with brine
  7. dry with materialfinally dried over sodium sulfate
  8. customBy evaporation of the solvent under reduced pressure 0.62 g of the product
  9. customare recovered

Sources & evidence

ORD record
ord-00dca5bad09545938128e7e21f77b58f
Source dataset
uspto-grants-2002_10
Patent number
US06472396B1

Reaction notes

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