Methanol → 5-(2-fluorophenoxy)-6-hydroxy-2-pyrazin-2-yl-1H-benzimidazole

HRID 99318Notes

Reaction equation

HRID 99318 reaction equation
[C+4:34].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]2[c:12]([nH:13][c:14](-[c:16]3[n:17][cH:18][cH:19][n:20][cH:21]3)[n:15]2)[cH:22][c:23]1[O:24][c:25]1[c:26]([F:31])[cH:27][cH:28][cH:29][cH:30]1.[CH3:42][OH:43].[H:32][H:33].[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1.[OH-:35].[OH-:37].[OH-:38].[OH-:39].[OH-:40].[OH-:41].[Pd+2:36]>>[OH:8][c:9]1[cH:10][c:11]2[c:12]([n:13][c:14](-[c:16]3[n:17][cH:18][cH:19][n:20][cH:21]3)[nH:15]2)[cH:22][c:23]1[O:24][c:25]1[c:26]([F:31])[cH:27][cH:28][cH:29][cH:30]1

Participants

8

Reactant 7

HCID 887MethanolHCID 961Hydroxide6×HCID 8028TetrahydrofuranHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 231455135-benzyloxy-6-(2-fluorophenoxy)-2-pyrazin-2-yl-1H-benzimidazoleHCID 178418361HCID 178418361, compoundHCID 178420935HCID 178420935, compound

Product 1

HCID 1356979845-(2-fluorophenoxy)-6-hydroxy-2-pyrazin-2-yl-1H-benzimidazole

Sources & evidence

ORD record
ord-8cddaced6ddc4ec1aa35e11e29d02ed8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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