Ethylene Glycol → 2-(2-Chloro-6-methoxyphenyl)acetic acid

HRID 993230Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1CC#N.[OH-:13].[K+].[CH2:15]([OH:18])[CH2:16]O>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[CH2:16][C:15]([OH:18])=[O:13]

Participants

Reactant 3

HCID 174Ethylene Glycol

HCID 14797Potassium Hydroxide

HCID 223275112-Chloro-6-methoxybenzeneacetonitrile

Product 1

HCID 223274882-(2-Chloro-6-methoxyphenyl)acetic acid

Procedure

325 g of 2-chloro-6-methoxyphenylacetonitrile are reacted with 171 g of potassium hydroxide in 690 ml of ethylene glycol. 331 g of solid are obtained (m.p. 164-165° C.).

Sources & evidence

ORD record: ord-e0f184c48bd34a22ab4d74065af3a5f3
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06472419B1

Reaction notes

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