Ethylene Glycol → 2-(2-Chloro-4-methoxyphenyl)acetic acid

HRID 993232Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1CC#N.[OH-:13].[K+].[CH2:15]([OH:18])[CH2:16]O>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:16][C:15]([OH:18])=[O:13]

Participants

Reactant 3

HCID 174Ethylene Glycol

HCID 14797Potassium Hydroxide

HCID 22327506(2-Chloro-4-methoxyphenyl)acetonitrile

Product 1

HCID 42091322-(2-Chloro-4-methoxyphenyl)acetic acid

Procedure

657 g (purity 75%) of 2-chloro-4-methoxyphenylacetonitrile are reacted with 303 g of potassium hydroxide in 1308 ml of ethylene glycol. 430 g of solid are obtained (m.p.: 83-86° C.).

Sources & evidence

ORD record: ord-e461ea3cd6c24fc3b0ca8ea67d8fff7c
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06472419B1

Reaction notes

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