反应详情

A mixture of 3-8 (0.40 g, 0.886 mmol), 20% Pd(OH)2 (0.40g), 1N NaOH (2 mL), and ethanol (20 mL) was shaken under 65 psig hydrogen in a Parr apparatus for 18 hours. The mixture was filtered through celite, and the filtrate concentrated. The residue was chromatographed on silica gel (25:10:1:1 to 15:10:1:1 EtOAc/EtOH/NH4OH/H2O) to give 350 mg of 3-9 as a white solid.

1. filtrationThe mixture was filtered through celite
2. concentrationthe filtrate concentrated
3. customThe residue was chromatographed on silica gel (25:10:1:1 to 15:10:1:1 EtOAc/EtOH/NH4OH/H2O)