反应详情

A mixture of ethyl 2-(4-fluorophenyl)-3-(4-(methylthio)phenyl)-3-oxopropanoate(1.33 g, 4 mmol), prepared according to the method of Example 1A(ii), hydrazine hydrate (0.25 mL, 4.2 mmol), and acetic acid (0.25 mL, 4.2 mmol) in dioxane (50 mL), and water (5 mL) was refluxed for 24 hours and then concentrated in vacuo. Water was added to the residue, and the solid was filtered and dried in vacuo to provide the desired product (yield: 1.15 g; 95%). MS (DCI-NH3) m/z 301 (M+H)+, 318 (M+NH4)+; 1H NMR (300 MHz, DMSO-d6) δ2.47 (s, 3H), 7.12 (t, J=9 Hz, 2H), 7.26 (m, 6H).

1. customprepared
2. temperaturewas refluxed for 24 hours
3. concentrationconcentrated in vacuo
4. additionWater was added to the residue
5. filtrationthe solid was filtered
6. customdried in vacuo