HCID 18409266, compound → HCID 18409316, compound

HRID 993469Notes

Reaction equation

HRID 993469 reaction equation
[CH2:1]([O:5][P:6]([O:33][CH2:34][CH2:35][CH2:36][CH3:37])([CH2:8]/[CH:9]=[CH:10]/[CH2:11][C:12]1([C:27]([NH:29][CH2:30][CH2:31][CH3:32])=[O:28])[C:24]2[CH:23]=[C:22]([F:25])[CH:21]=[CH:20][C:19]=2[C:18]2[C:13]1=[CH:14][C:15]([F:26])=[CH:16][CH:17]=2)=[O:7])[CH2:2][CH2:3][CH3:4]>[Pd]>[CH2:34]([O:33][P:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])([CH2:8][CH2:9][CH2:10][CH2:11][C:12]1([C:27]([NH:29][CH2:30][CH2:31][CH3:32])=[O:28])[C:13]2[CH:14]=[C:15]([F:26])[CH:16]=[CH:17][C:18]=2[C:19]2[C:24]1=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)=[O:7])[CH2:35][CH2:36][CH3:37]

Participants

3

Reactant 1

HCID 18409266HCID 18409266, compound

Product 1

HCID 18409316HCID 18409316, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

An ethanol solution of Example 195 compound (260 mg, 0.49 mmol) containing 50 mg of 10% palladium on carbon was stirred under a hydrogen atmosphere (balloon) for 14 hrs. The reaction was filtered through a 0.2 μm nylon filter to remove the catalyst and the solvent evaporated yielding 235 mg (90%) of title compound as a colorless oil.

Workup

  1. filtrationThe reaction was filtered through a 0.2 μm nylon
  2. filtrationfilter
  3. customto remove the catalyst
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-647aa2b45d8648398e0092b1cd8ba9d2
Source dataset
uspto-grants-2002_10
Patent number
US06472414B1

Reaction notes

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