Sodium Hydroxide → 4-Bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-5-hydroxybenzoic acid

HRID 993487Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 993487
C([O:3][C:4](=[O:24])[C:5]1[CH:10]=[C:9]([OH:11])[C:8]([Br:12])=[C:7]([O:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=2[Cl:23])[CH:6]=1)C.[OH-].[Na+]>C(O)C.O>[Br:12][C:8]1[C:9]([OH:11])=[CH:10][C:5]([C:4]([OH:24])=[O:3])=[CH:6][C:7]=1[O:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=1[Cl:23]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 574196834-Bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-5-hydroxybenzoic acid ethyl ester

Produkt 1

HCID 220524124-Bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-5-hydroxybenzoic acidAusbeute 31 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 25.6 g (59 mmol) of 4-bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-5-hydroxybenzoic acid ethyl ester in 300 ml of ethanol and 2.36 g (65 mmol) of sodium hydroxide in 15 ml of water was stirred at room temperature for 12 h. The solvent was removed and the residue was distributed between water and ethyl acetate. The aqueous solution was acidified with 1 N HCl and the precipitate was filtered to give 4.35 g (31%) of the title compound.

Aufarbeitung

  1. customThe solvent was removed
  2. filtrationthe precipitate was filtered

Quellen und Nachweise

ORD-Eintrag
ord-1eb26ddd61c64daf826c404d8b876b90
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06472562B1

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