1,4-Dioxane → 5,7-Difluoro-6-vinyl-quinoline
Reaction equation
[Br:1][c:2]1[c:3]([F:13])[c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[cH:10][c:11]1[F:12].[CH2:14]([CH2:15][CH2:27][CH3:28])[Sn:16]([CH2:17][CH2:18][CH2:19][CH3:20])([CH2:21][CH2:22][CH2:23][CH3:24])[CH:25]=[CH2:26].[O:106]1[CH2:107][CH2:108][O:109][CH2:110][CH2:111]1.[cH:29]1[cH:30][cH:31][c:32]([P:33]([Pd:34]([P:35]([c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)([P:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[P:73]([c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)([c:92]2[cH:93][cH:94][cH:95][cH:96][cH:97]2)[c:98]2[cH:99][cH:100][cH:101][cH:102][cH:103]2)[cH:104][cH:105]1>>[c:2]1([CH:14]=[CH2:15])[c:3]([F:13])[c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[cH:10][c:11]1[F:12]Participants
5
Sources & evidence
- ORD record
- ord-b4ed739ccba94206b19808d4d2b8d93c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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