1,2-二氨基-3-甲氧基苯 (HCID 184268)

名称与标识

首选名称: 3-Methoxybenzene-1,2-diamine
IUPAC: 3-methoxybenzene-1,2-diamine
中文名: 1,2-二氨基-3-甲氧基苯
英文名: 3-METHOXY-BENZENE-1,2-DIAMINE
分子式: C7H10N2O
分子量: 138.17

名称与别名

3-methoxybenzene-1,2-diamine37466-89-03-Methoxy-1,2-benzenediamineDTXSID20276664RefChem:503232DTXCID00199286815-861-52,3-diaminoanisole2,3-DIAMINOANISOL3-methoxy-benzene-1,2-diamine3-Methoxy-o-phenylenediamine3-Methoxy-1,2-phenylenediamine

展开更多名称

3-甲氧基邻苯二胺埃索美拉唑杂质29埃索美拉唑杂质45埃索美拉唑杂质812,3-二氨基苯甲醚3-甲氧基-O-苯二胺2-氨基-3-甲氧基苯胺3-甲氧基-1,2-苯二胺3-甲氧基苯-1,2-二胺1,2-二氨基-3-甲氧基苯NSC 521887Esomeprazol Impurity 7Esomeprazole Impurity 293-Methoxy-2-amino-aniline1,2-Diamino-3-methoxybenzene3-Methoxy-1,2-diaminobenzene

1,2-Benzenediamine, 3-methoxy-diaminoanisoleMFCD082769033-Methoxyphenylene-1,2-diamineNSC521887Esomeprazole Impurity 1hydrosulphate2-amino-3-methoxyaniline

数据库标识

CAS: 37466-89-0
PubChem CID: 184268
DTXSID: DTXSID20276664
EC Number: 815-861-5
Nikkaji: J1.115.481F

性质

结构计算性质

XLogP: 0.5
极性表面积: 61.3 Å²
氢键供体: 2
氢键受体: 3
可旋转键: 1
重原子: 10
形式电荷: 0
复杂度: 108

物理化学性质

熔点: 77 · 77-78℃
沸点: 114 · 114-116 °C(Press: 0.5 Torr)
密度: 1.17 · 1.170±0.06 g/cm3(Predicted)
储存条件: Keep in dark place,Inert atmosphere,Room temperature
溶解度: Chloroform (Slightly), Methanol (Slightly)
酸度系数(pKa): 4.1 · 4.10±0.10(Predicted)
形态: solid
颜色: Black
水溶解性: Slightly soluble in water.
敏感性: Air Sensitive
CAS 数据库: 37466 · 37466-89-0

安全与法规

GHS分类

GHS Classification · 5 条

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]；H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

危害信息

Hazard Classes and CategoriesAcute Tox. 4 (100%)；Acute Tox. 4 (100%)；Skin Irrit. 2 (100%)；Eye Irrit. 2 (100%)；Acute Tox. 4 (100%)；STOT SE 3 (100%)

安全数据

危险等级: 6.1
海关编码: 2922290090

化学与工业

制备方法 · 1 条

生产方法以2-硝基-3-甲氧基苯胺为原料合成1,2-二氨基-3-甲氧基苯的一般步骤：向2-硝基-3-甲氧基苯胺（90 mg，0.54 mmol）的乙醇（3 mL）溶液中加入5%钯碳催化剂（18 mg，20 wt%）。将反应混合物在室温下于氢气氛围中搅拌18小时。反应完成后，通过硅藻土过滤去除催化剂，随后蒸发滤液，得到目标产物3-甲氧基-1,2-苯二胺（73 mg，产率100%）。参考文献：[1] Patent: WO2006/50506, 2006, A1. Location in patent: Page/Page column 126[2] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 11, p. 3441 - 3444[3] Patent: EP2168959, 2010, A1. Location in patent: Page/Page column 121[4] Patent: EP2168960, 2010, A1. Location in patent: Page/Page column 61-62[5] Patent: US2011/301170, 2011, A1. Location in patent: Page/Page column 29