六水硝酸铽 → HCID 86588302，化合物

HRID 1007076

反应方程式

HRID 1007076 反应方程式
[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:7][S:8]([C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)(=[O:10])=[O:9])[CH:3]=1.[N+:18]([O-:21])([OH:20])=[O:19]>CO.C(#N)C>[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH:3]=1.[N+:18]([O-:21])([O-:20])=[O:19]

参与物

5

反应物 2

HCID 944六水硝酸铽HCID 5329磺胺甲恶唑

产物 1

HCID 86588302HCID 86588302，化合物收率 60%

试剂、催化剂与溶剂 2

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂HCID 6342乙腈溶剂

实验过程

The compound is prepared by starting from a Sulfamethoxazole solution (2 g, 7.9 mmoli) in methanol (100 ml), addition of a 65% nitric acid solution (0.500 ml) in acetonitrile (5 ml), following the procedure reported in Example 5. Sulfamethoxazole nitrate as amorphous solid is obtained. Yield 60%.

后处理

  1. customThe compound is prepared

来源与证据

ORD记录
ord-7e868392ac6d4e0dbe7cd7f6fb4e6bd2
来源数据集
uspto-grants-2004_09
专利号
US06794372B2

关联笔记

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