丙酮酸 → HCID 178432270，化合物

HRID 1056243

反应方程式

HRID 1056243 反应方程式
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:10](O)(=[O:14])[C:11]([CH3:13])=O>CO>[Cl:9][C:3]1[C:2]2=[N:1][C:10]([OH:14])=[C:11]([CH3:13])[N:8]=[C:7]2[CH:6]=[CH:5][N:4]=1

参与物

4

反应物 2

HCID 1060丙酮酸HCID 2857362-氯-3,4-二氨基吡啶

产物 1

HCID 178432270HCID 178432270，化合物收率 65.7%

试剂、催化剂与溶剂 1

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

反应条件

温度
50 °C

实验过程

A mixture of 3,4-diamino-2-chloropyridine (2.1 g, 14.63 mmol) (Sigma Aldich) and pyruvic acid (1.22 mL, 17.55 mmol) (Acros, New Jersey) in MeOH (40 mL) in a sealed glass tube was heated at 50° C. for 2 h. The mixture was cooled to RT and the solvent was removed in vacuo. The residue was triturated with ether and the suspension was filtered to give 1.88 g of crude product. MS (ESI, pos. ion) m/z: 196.1 (M+1).

后处理

  1. temperatureThe mixture was cooled to RT
  2. customthe solvent was removed in vacuo
  3. customThe residue was triturated with ether
  4. filtrationthe suspension was filtered

来源与证据

ORD记录
ord-5c3cc1e123fc447d8c33780bcb59abdc
来源数据集
uspto-grants-2016_07
专利号
US09394297B2

关联笔记

加载中…