Government regulation → Methyl 6-bromo-5-oxohexanoate

HRID 1057504笔记

反应方程式

HRID 1057504 反应方程式
[C:1]([CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10]C)=[O:8])(=[O:3])[CH3:2].[Br:12]Br>CO>[Br:12][CH2:2][C:1](=[O:3])[CH2:4][CH2:5][CH2:6][C:7]([O:9][CH3:10])=[O:8]

参与物

4

反应物 2

HCID 24408Government regulationHCID 841304-乙酰基丁基乙酯

产物 1

HCID 582216Methyl 6-bromo-5-oxohexanoate

试剂、催化剂与溶剂 1

HCID 887Methanol溶剂

反应条件

温度
0 °C

实验过程

Ethyl 4-acetylbutyrate was dissolved in MeOH (0.5M) and cooled to 0° C. Bromine (1.0 eq) was added dropwise and the mixture was stirred at room temperature for 18 hrs. The solvent was removed in vacuo and the residue was dissolved in ether, washed with water, saturated sodium bicarbonate, brine, dried over sodium sulfate. The solvent was removed in vacuo and the residue was purified by flash chromatograpy (7% EtOAc/Hexanes). EI-MS m/z 224 (M+H)+.

后处理

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in ether
  3. washwashed with water, saturated sodium bicarbonate, brine
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed in vacuo
  6. customthe residue was purified by flash chromatograpy (7% EtOAc/Hexanes)

来源与证据

ORD记录
ord-6f5fcd12af6c4ed4877937219857f1b5
来源数据集
uspto-grants-2003_02
专利号
US06514964B1

反应笔记

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