碳酸钾 → 4-氨基哌啶-1-甲酸苄酯

HRID 1078

反应方程式

HRID 1078 反应方程式
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2C(=O)C3=CC=CC=C3C2=O)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.NN.C([O-])([O-])=O.[K+].[K+]>C(O)C.[Cl-].[Na+].O>[NH2:17][CH:14]1[CH2:13][CH2:12][N:11]([C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:10])[CH2:16][CH2:15]1

参与物

6

反应物 3

HCID 11430碳酸钾HCID 24654水合肼HCID 21831105Phenylmethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-piperidinecarboxylate

产物 1

HCID 178466404-氨基哌啶-1-甲酸苄酯收率 85%

试剂、催化剂与溶剂 2

HCID 702乙醇溶剂HCID 57417360Sodium chloride; water溶剂

反应条件

温度
100 °C

实验过程

1-Benzyloxycarbonyl-4-phthalimidylpiperidine (1.50 g, 4.27 mmol), prepared in Example 16B, was taken up in 20 mL of ethanol. To this solution was added hydrazine monohydrate (35 mL, 700 mmol) and this mixture was heated at 100° C. for 3 h. Brine solution (40 mL) and 10% aq. K2CO3 (60 mL) were added and the mixture was extracted with 5% MeOH/CHCl3 (3×). The combined extracts were washed with 2N aq. HCl, 2N aq. NaOH, brine solution, dried over Na2SO4 and concentrated to give 0.847 g, (85%) of 4-amino-1-benzyloxycarbonylpiperidine. [1H]-NMR(CDCl3) consistent with structure.

后处理

  1. extractionthe mixture was extracted with 5% MeOH/CHCl3 (3×)
  2. washThe combined extracts were washed with 2N aq. HCl, 2N aq. NaOH, brine solution
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

来源与证据

ORD记录
ord-2cac9a20d7c04458add12877e56c0bdb
来源数据集
uspto-grants-1998_03
专利号
US05723490

关联笔记

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