Diisopropylamine → N,N-二异丙基氯亚磷酰胺(2-氰基乙基)酯

HRID 131069笔记

反应方程式

HRID 131069 反应方程式
[Cl:1][P:2](Cl)[O:3][CH2:4][CH2:5][C:6]#[N:7].[CH:9]([N:12]([CH:15]([CH3:17])[CH3:16])CC)([CH3:11])[CH3:10].C(NC(C)C)(C)C>ClCCl.CN(C1C=CN=CC=1)C>[CH:9]([N:12]([P:2]([Cl:1])[O:3][CH2:4][CH2:5][C:6]#[N:7])[CH:15]([CH3:17])[CH3:16])([CH3:11])[CH3:10]

参与物

6

反应物 3

HCID 7912DiisopropylamineHCID 81531N,N-二异丙基乙胺HCID 1958972-氰乙基二氯磷酸酯

产物 1

HCID 2734844N,N-二异丙基氯亚磷酰胺(2-氰基乙基)酯

试剂、催化剂与溶剂 2

HCID 142844-二甲氨基吡啶(DMAP)催化剂HCID 6344二氯甲烷溶剂

实验过程

To a solution of 0.54 mL (4.0 mmol) of dichloro(β-cyano)ethoxyphosphine in 40 mL of dichloromethane cooled in an ice-water bath was added 10 mL of diisopropylethylamine, followed by adding 0.64 mL (4.0 mmol) of diisopropylamine under Argon. The reaction mixture was warmed up to room temperature and stirred for 2 h. After adding 0.1 gm of DMAP into the solution, the reaction mixture is ready for the next step reaction.

后处理

  1. customthe reaction mixture is ready for the next step reaction

来源与证据

ORD记录
ord-d98849336d4a4b7bbe9bd902f8129827
来源数据集
uspto-grants-2008_06
专利号
US07384749B2

反应笔记

加载中…