3-N-叔丁氧羰基胺基环丁胺 → tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate

HRID 136笔记

反应方程式

HRID 136 反应方程式
CC(C)(C)OC(=O)NC1CNC1.COc1cc(Br)ccn1>CC(C)(C)[O-].Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>COc1cc(N2CC(NC(=O)OC(C)(C)C)C2)ccn1

参与物

7

反应物 2

HCID 15194053-N-叔丁氧羰基胺基环丁胺HCID 140623094-溴-2-甲氧基吡啶

产物 1

HCID 118055029tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate收率 100.28%

试剂、催化剂与溶剂 4

HCID 23676156叔丁醇钠试剂HCID 634876R-(+)-1,1'-联萘-2,2'-双二苯膦催化剂HCID 9811564三(二亚苄基丙酮)二钯催化剂HCID 1140甲苯溶剂

反应条件

温度
70 °C

实验过程

A mixture of all the reactants in toluene was heated in a sealed vial at 70 °C overnight. According to LC-MS the reaction was completed and the product had been formed. Toluene was removed, water was added and the product was extracted with DCM. The organic phase was dried through phase separator and concentrated. The crude was used without further purification in the next step, EN01762-02.

来源与证据

ORD记录
ord-3870c5bc1f6548e38bd05a0e29b91f59
来源数据集
750 AstraZeneca ELN dataset
原始链接
查看来源

反应笔记

加载中…